CLASSIFICATION OF CRUDE DRUGS

Saturday, January 29, 2011



 There are following methods of classification.
1.      Alphabetic method of classification
2.      Chemical method of classification.
3.      Pharmacological method of classification.
4.      Morphological method of classification.
5.      Taxonomical method of classification.
6.      Chemo- taxonomical method of classification.
1.       Alphabetic Method of Classification
In this method drugs are classified according to first alphabet of their English or Latin name. This method is adopted in many books like I. P. (Indian Pharmacopoeia) N.P. (National formulary) U.S (United states Pharmacopoeia), B.P. In I.P.1955 drugs where given according to Latin name. In I. P. 1966 names changed in to English.
Amylum Changed in to starch
Acacia changed in to Indian gum.
Advantages: -If we know the name of drug, we can study it properly.
2.    Chemical Method of Classification: -
Drugs are classified according to their active chemical constituent. Drugs which
Contain similar chemical are grouped in one place.
Chamical Content
Drugs
1. Volatile oil                       
2. Alkaloid                            
3.Glycoside                                    
4.Fixed oil& fat                              
5. Carbohydrates                          
6.Vitamins                                      
7. Lipid                     
Fennel oil, coriander.
Rauwolfia, Datura Nuxvomica, Cinchona,and Vinca
Senna leaf, Digitalis.
Arachis oil, sesame oil, castor oil
Acacia, Honey, starch, Isapgol
Shark liver oil, cod liver oil wheat, Germ oil, Amla.
Castor oil, peanut oil, mustard, and wool fat

 Disadvantages: -
 1.      This method does not give any idea about source of drug.
 2.      Some drugs contain two important chemicals so it is difficult to classify them.
     e. g. Nutmeg contains volatile oil as well as fat. Cinchona contains glycoside                
            as well as alkaloid.
 3.      No idea whether drug is organized or unorganized.
Advantages: -
If we know chemical constituent. It is easy to study the drug.
Pharmacological Classification: -
The drugs having similar pharmacological effect in body are grouped together.
Pharmacological Action
Drug
1. Carminatives      
Fennel, Dill, Coriander, and Clove.
2.  Purgatives                     
Cascara- sagrada, Aloe, Senna, and Rhubarb.
3.  Cardio tonics                                        
Digitalis, squill, and strophanthus
4.   Anthelmintic     
Artemisia, Male- fern, and Quassia
5.  Anti- cancer       
Podophyllum, Vinca
6.  CNS Stimulant              
Nuxvomica
7.  Expectorant                               
Vasaka, Liquoric
8.  Bitter tonic                     
Gentian, Cinchona, and Nux vomica
 Disadvantages: -
1.         Some crude drugs have two different pharmacological actions therefore it is difficult to classify them. E.g. Nux- vomica is CNS stimulant as well as bitter tonic. Cinchona is bitter tonic as well as Antimalarial & Antipyretic.
2.         Drugs that have different mechanism of action have to be grouped together.
e. g. Castor oil is irritant purgative & Isapgol is bulk purgative but they are placed in one group.
3.         No idea whether drugs are organized or unorganized
4.         This method does not give any idea of source of drugs.
Advantages: -
If we know pharmacological action it is easy to study the drug.

Morphological Classification: -
In this method drugs are divided into parts of plants like, Roots, Flowers, Leaves, Wood, Extracts, Gum, Bark.
 Part of Plant
                                    Drugs
Fruit
Caraway, Fennel,
Seed:
Nuxvomica, Nutmeg, colchicum
Bark: 
Arjuna, Cinchona, cinnamon
Gum: 
Acacia, Tragacanth, Streculia, and Guargum
Latex:           
Opium, Papaya
Extract:        
Catechu, Agar, and gelatin.
Leaf: 
Coca, Digitalis, Senna, and Vasaka.
Advantages: -
1.         It is more convenient for practical purpose.
2.         Even if the chemical content or action of drug is not known the drug can be studied properly.
3.         It gives idea about source of drugs
4.         It gives idea whether it is organized / unorganized.
Disadvantages: -
During collection, drying & packing morphology of drug changes. They are difficult to study.
Taxonomical Classification: -
It is purely biological classification. Drugs are given according to position of plant in plant kingdom. It is difficult system.
Disadvantage: -
No idea about organized / unorganized.
Fennel: -
Division                      -           Angiosperm.
Class                          -           Dicotyledonae
Order                          -           Umbelliflorae.
Family                         -           Umbelliferae.
Example                     -           Fennel.
Chemo taxonomical: -
This is recent type of classification in which equal importances have been given to family of plant & it's chemical constituents. It has been found that there is closed relationship between chemical composition of the plant and its position in plant kingdom.
Ex. plants of Umbeliferae contain volatile oil, plants of Solanaceae, Apocyanaceae contain alkaloid.
  • Pharmacognosy is defined as scientific & systematic study of structural, physical, chemical & biological characters of crude drugs along with history, method of cultivation, collection & preparation for the market.
  • Crude Drugs: - Crude drugs are the drugs, which are obtained form natural sources like plant. Animals , minerals & they are used as such as they occur in nature without any processing except, drying & size reduction.
 Source
Example
Vegetable Source
Fennel, Dill, Clove and Senna
Animal Source
Honey, Bees wax, Shark liver Oil
Mineral Source
Talc, Chalk, Bentonite
 Work of Seydler.
Seydler was German scientist he wrote a book " Analecta Pharmacognistica " in 1815. In this book he used word pharmacognosy first time he coined (to Prepare) this word by combining two Greek words
1) Pharmakon: - Drug
2) Gignosco: - To acquire knowledge of 
2)  Work of Galen:  - (131 - 200)
Galen was Greek pharmacist; he worked on extraction of chemical constituent from the plants. He developed various methods of extraction therefore the branch of pharmacy which deals with extraction of chemical constituent from plants & animals is called as galenical Pharmacy.
3)   Hippocrates (460 - 360. B.C.)
Before the birth of Jesus. He was Greek scientist; he worked on human anatomy & Physiology Particularly on circulatory system & nervous system. He prepared famous oath for physicians, which is still taken by the physicians. He is known as father of medicine.
    4)    Indian History Of Pharmacognosy: -
It is about 5500 years old, in the suktas of Rigveda & Atharwaveda medicinal property of plant is given. There are several medicinal plants, which are given with there use. The old Ayurveda Books, Charak samhita & Sushrutsamtita described many medicinal plants.
5)   Traditional Indian System of medicine (Indigenous) i. g. old system.
a) Ayurveda: - The old system of treatment in India. It is 5500 years old. Ayurveda believes there are 3 principles 1) cough. 2) Vat. 3) Pitta. Which are responsible to maintain health. If their equilibrium is disturbed persons suffers from diseases
Ayurveda cures the cause of disease. The principles of positive health and therapeutic measures embedded in this system relate to mental, physical, social and spiritual welfare of human beings. Drugs of Ayurveda are obtained mostly from plants.
Dosage of Ayurveda are 1) Bhasma (oxides of metals) 2) Quath (extracts) 3) Gutika (pills) 4) Lep (ointment) 5) Asava & Arishtha (Alcohol containing liquids.) 6) powder. 7) Medicated oils. There are eight braches of Ayurveda.
1.      Kayachikitsa (Internal medicine)
2.      Kumarbhritya (pediatrics)
3.      Trachchikitsa (psychological medicine)
4.      Shalakya Tantra [(CENT) Ears, Nose & throat]
5.      Shalya Tantra (surgery)
6.      Agada tantra (toxicology)
7.      Rasayana tantra (geriatrics- medicines for the old persons)
8.      Vajikaran tantra [Aphrodisiacs, drugs which are sexual stimulants.]
Sidha System of Medicine.
The "Siddhas" developed the Sidha system of medicine (Spiritual persons). It is old than ' Vedic culture ' it belongs to Dravidian culture. Like Ayurveda the medicines are prepared from plants. The literature of this system is given in Tamil Language. Like Ayurveda it believes that all objects in universe, are made from 5. Elements. 1) Earth. 2) Water. 3) Sky. 4) Air. & 5) Fire.
Diseases are identified by examination of pulse, voice, colour, of urine, tongue, and shadow. Etc. The books are written in Tamil.
 Naturopathy & yoga: -
Naturopathy is not only a system of treatment but it also teaches the way of living. In naturopathy use of soil & water is important in treatment of diseases mudpacks & steam baths are used. Fasting is also used to treat diseases.
Yoga consists of two parts: -
1.Exercises (physical postures). 2. Meditation
1.       Exercises: -  Improves blood circulation in the body.
2.         Meditation: - consists of 1) Breathing exercise 2) observance of austerity, 3) physical postures 4) Restraining of sense organ,, 5) Contemplation, 6).meditation & 7) samadhi.
This system helps us to improve physical, mental & social health. It improves personal behavior of the person.
DEFINATIONS
1)     Carminative: -The Agent, which expels gases from G. I. tract, is known as carminative.
e. g. Fennel, Dill, Caraway
2)     Expectorant: - The drug / agent which increases Fluidity of cough & helps in easy removal of cough are known as expectorant.
e. g. Vasaka, Tolu-balsam, Benzoin.
3)     Purgative: - The drug which evacuate the bowl
e. g. Senna leaf, Castor oil,  Rhubarb.
4)     Laxative: - These are the purgatives, which have mild action.
e. g. senna
5)     Cathartic: - These are drastic purgative stools produced are watery in nature.
e.g. Castor oil, Rhubarb.
6)     Analgesic: - The drugs which relieves pain by acting on Central Nervous System. They are of two types
I)                    Narcotic Analgesics e. g. Opium
II)                   Antipyretic Analgesics e. g. Aconite
7)     Antipyretic Analgesics: - The drug, which reduces, elevated body temp.
e. g. Cinchona bark
8)     Diaphoretic: - Drug, which reduces, elevated body temperature by increasing rate of sweating.
e. g. Tulsi, Camphor Tulsi, Camphor
9)     Diuretic: - The drug, which increases rate of Formation & excretion of urine, is known as diuretic.
e. g. Tea, Buchu leaves
10) Emetic: - The drug which produces vomiting.
e. g. Mustard, Ipecac Senega.
11) Febrifuge: - The drug which reduces the body temperature.
12) Hypnotic: - The drug which produces sleep, like Natural sleep, is known as Hypnotic e. g. Opium
13) Sedative: - The drug, which lowers activity of any organ or central Nervous System, is known as sedative. (Tranquillizer.)
     14)  Oxytocic: - The drug which causes contraction of uterus.
e. g. Ergot
15) Anthelmintic: - The drug, which kills or expels, worms from G. I. T.
e. g. Santonica flower, Chenopodium oil.
16) Appetizer: - The drug which increases desire for food
e. g. Cinchona, Nux-vomica.
17) Aphrodisiac: - An agent which stimulate sexual desire
e. g. lahsun.
18) Bitter: - Bitters are drugs having bitter taste, due to bitter taste they stimulate nerves and stimulate secretion of stomach and appetite.[S1] e.g. Cinchona, Nux vomica.
19) Counter irritant: - Counter irritant is a substance, which when applied is externally produces irritation. This irritation is mild in nature, this irritation reduce the original pain sensation.
e. g. Camphor, Turpentine oil, methyl salicylate.
20) Stomachic: - The drug, which increases secretion of gastric juice & function of stomach, digestion is known as stomachic   e. g. Fennel, Dill, Gentian.

PHARMACOGNOSY



DEFINATION
      The term Pharmacognosy has been derived from the 2Greek words: I) pharmakon, which means a drug & ii) gnosis, which means knowledge of or gignosco, which means to acquire knowledge of. Thus the full meaning of the term Pharmacognosy is `knowledge of drugs’ or `to acquire knowledge of drugs’.
Pharmacognosy is the objective study of crud drugs & related substances.
Pharmacognosy is an applied science which is concerned with acquiring knowledge of crud drugs by the application of various scientific disciplines.
SCOPE
      Pharmacognosy is an important branch of Pharmacy, which is concerned with the study of crud drugs & natural products of pharmaceutical importence.
It deals with the scientific study of structural, physical, chemical & sensory characters of crud drugs obtained from plant, animal & mineral source.
It also includes the study of their history, distribution, cultivation, collection, preparation, identification, evaluation, preservation & commerce.
SUBJECT MATTERS OF PHARMACOGNOSY
 Pharmacognosy deals with the study of,
Naturally occurring substances having medical properties
Crud drugs & other natural substances of pharmaceutical importences
Chemical constituents of crude drugs & medicinal plants
Natural substances used as excipients or pharmaceutic necessities in the formulation & preparation of pharmaceutical &medicinal products. These include:
i) colouring & flavouring agents, ii) suspending agents, iii) diluents & disintegrating agents, iv) sweetening agents, v) binders, adhesives, solifyding agents, etc.
SUBJET MATTERS
      Substances, which are used as medical & pharmaceutical practices. Example of which include:
a) fibers & surgical dressings, b) anesthetic acids, c) filtering agents, such as diatomite & asbestos, d) basses & vehicles, such as agar, gelatin, wax, fixed oils & fats.
      Beverages with medicinal constituents, e.g. tea, coffee & cocoa which contain caffeine.
      Spices & condiments, which have medicinal properties, e.g. Cinnamon, Cardamon, Umbelliferous fruits (Coriander, Fennel, Cumin, etc.), Mustard seed, Clove, Ginger, Garlic, etc.
      Vitamins, enzymes, antibiotics, allergens, pesticides, etc.
Medicinal plants. &  Traditional medicine.
HISTORICAL DEVELOPMENT OF PHARMACOGNOSY
      Pharmacognosy is regarded as the mother of all science.
      History of pharmacognosy represents the history of pharmacy & medicine.
      Pharmacognosy had its origin in the health-related activities of the most primitive human race of the remote past.
      The early man sought to alleviate his sufferings of illness & injuries by using plants.
      They acquired knowledge of medicinal properties of plants in the following way:
a)  By guesswork or trial & error
b)  While searching for food
c)  By superficial resemblance between the plant parts & the affected organs, that is, by examining the “Signature of Nature”
d)  By observing other animals instinctive discrimination between toxic & palatable plants
e)  By accidental discovery
      By a combination of all these means the ancient people acquired a considerable volume of knowledge about drugs.
      In course of time a group of people emerged in each community who acquired expertise in collecting, testing & using medicinal plants for treating diseases. These people later became known as `Medicine Men'.
      The Medicine Men monopolized the knowledge of drugs and hide that knowledge in some mysterious incantations. They transferred this secret knowledge only to their trusted predecessors of the successive generations, who gradually increased the volume of knowledge about drugs and their uses.
      Initially the transfer of the acquired knowledge from generation to generation used to be done verbally by the use of signs & symbols. As civilization progressed, transfer and recording of the knowledge were done in writing.
According to recorded history:
      Babylonians (about 3000 BC) had knowledge of large number of medicinal plants and their properties.
      Some of the plants used are still used almost in the same way and for the same purposes.
      The Chinese pharmacopoeia, Pen Tsao, written between 3000 and 2730 BC, includes recipes and therapeutic uses of many Chinese traditional medicines.
      Ebers Papurus, written in 1550 BC, recorded that Egyptians possessed a good knowledge of human anatomy & medicinal uses of hundreds of plants which made them capable of embalming dead bodies for making mummies.
      Many of the present day drugs, such as Henbane, Mandrake, opium, Pomegranate, Caster oil, Aloe, Onion, many fixed oils & fats, were in common use in Egypt about 4500 years ago.
      The earliest plant medicines used in the Ayurvedic system were described around 1200 BC with a list of 127 plants.
      The Greek civilization witnessed a highly developed system of medicine which used medicinal plants and minerals. Arab Muslims further enriched this system and developed the Greco-Arabic or Unani system, which formed the basis of modern Allopathic system of medicine.     
The following people contributed significantly to the gradual development of Pharmacognosy:
      Hippocrates (460-370 BC). He is regarded as the `Father of medicine' for his contribution to human anatomy and physiology. He collected, identified and used a large number of medicinal plants.
      Aristotle (384-322 BC). A student of great philosopher Plato listed more than 500 plants of medicinal importance with their description & uses.                                        
Theophrastus (370-287 BC) collected, identified a large number of medicinal plants and recorded their medicinal properties.
      Dioscorides (1st Century AD), a Greek Physician, published five volumes of a book, entitled `De Materia Madica'  in 78 AD, which described more than 600 medicinal plants with their collection, storage & uses.
      Pliny de Elder (23-70 AD), a Greek botanist, collected and described a large number of medicinal plants with their uses.
      Galen (131-200 AD), a Greek pharmacist-physician, described methods of preparing pharmaceutical formulations containing plant and animal drugs. These methods & his other observations on medicinal plants have been recorded in as many as 20 volumes of books. The present day Galenical preparations or Galenicals are prepared according to those methods.
      So long the same person, the apothecary (pharmacist-physician), used to do all the works of collection, processing, preparation and dispensing of the medicaments (the works of the pharmacist) and also diagnosing the disease and prescribing the drug (the works of the physician).
      With the increase of knowledge of drugs, the volume of work also increased a lot and it become impossible for one person to manage them properly.
Thus at this point pharmacy & medicine started developing along two separate paths:
      a) One group specialized in diagnosing the disease and prescribing the drug and became known as the physicians or doctors;
      b) The other group specialized in collecting, processing, preparing & dispensing the drug and became known as the apothecaries or pharmacist.
In this way, Pharmacognosy progressed gradually and formed the basis and beginning of both pharmacy & medicine.
                                           

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